Arsinée Khanjian was born in 1958 in Beirut, Lebanon in family of Armenian refugees. Her parents moved to Canada when she was seventeen. She is married to Canadian filmmaker Atom Egoyan, who regularly casts her in his films, in addition to her independent work and stage roles. She has a bachelor's degree in French and Spanish from Concordia University and a master's degree in political science from the University of Toronto. Her husband, Egoyan, credits her for inspiring him to further explore his Armenian roots. She lives in Toronto with her husband and their son, Arshile.
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